Mechanical, physical–chemical and biological properties of the new Ti–30Nb–13Ta–5Zr alloy

A technology was developed to obtain homogeneous Ti–30Nb–13Ta–5Zr alloy. The alloy was shown to consist of a pure β-crystalline phase and possesses requisite mechanical properties. The alloy surface exhibits micro- and nanoscale structures. In terms of the ability to generate reactive oxygen species and long-lived reactive protein species, Ti–30Nb–13Ta–5Zr alloy is more favorable compared to nitinol. A high mitotic index (2%) and low content of non-viable cells (< 5%) were observed when growing cell cultures on Ti–30Nb–13Ta–5Zr alloy scaffolds. Cells readily attach and spread over the alloy surface. The biocompatibility of Ti–30Nb–13Ta–5Zr was confirmed by the results of implantation of the alloy in the form of plates or looped wire. Surface morphology of the samples showed no significant changes after biological testing. It can be assumed that Ti–30Nb–13Ta–5Zr is a material potentially suitable for use in medicine.