Effects of the mineral bone component on the structural and functional state of bone tissue under modeling microgravity and glucocorticoid osteoresorption

The known negative consequences of space flights on the cosmonaut’s bone system have long been established and require the development of preventive measures in order to provide the possibility of subsequent prolonged space missions. However, the mechanisms underlying these changes in bone tissue occurring in microgravity are still unknown. Another significant factor in reducing bone mass is the use of glucocorticoids as a widespread anti-inflammatory agent. This fact also demonstrates the necessity to find a highly effective preventive remedy. Previously studied properties of the mineral bone component (MBC) perfectly characterize it from the point of view of the possibility of using it as a similar remedy. In this work, it was found that the introduction of a mineral bone component in experimental animals against the background of simulated microgravity and hydrocortisone injections has a favorable effect on the state of bone tissue, which was demonstrated by data from osteometric and X-ray analysis.