Clinical application of fine needle aspiration cytology combined with thyroghobulin measurement during the postoperative follow-up of differentiated thyroid carcinoma

Objective To explore the diagnostic value in fine needle aspiration cytology combined with thyroghobulin measurement of suspected malignant cervical enlarged lymph node in differentiated thyroid carcinoma. Methods The study included 82 patients with differentiated thyroid carcinoma who were found suspected metastatic lymph nodes in neck during follow-up and accepted reoperation from January 2015 to May 2017.Ultrasound-guided fine-needle aspiration was done in 130 suspected malignant lymph nodes, at the same time, thyroghobulin in fine needle aspiration cytology washout fliud was measured with electrochemiluminescence, fine needle aspiration cytology combined with thyroglobulin measurement in fine-needle aspiration biopsy.All suspicious malignant lymph nodes were precise positioning preoperative by injection of nanocarbon suspension under guidence of ultrasound.The analyze was performed according to the final pathological diagnosis after operation. The sensitivity, specificity and accuracy of fine needle aspiration cytology, thyroglobulin measurement in fine-needle aspiration biopsy, fine needle aspiration cytology and thyroglobulin measurement in fine-needle aspiration biopsy were calculated by Fomage′s statistical method and χ2 test was used for comparison among groups. Results Eighty-two patients with 130 lymph nodes with definitemarkers and pathological diagnosis, with a pathological examination of 119 and negative 11 cases.The sensitivity of fine needle aspiration cytology, thyroglobulin measurement in fine-needle aspiration biopsy, fine needle aspiration cytology and thyroglobulin measurement in fine-needle aspiration biopsy was 88.2%, 94.1% and 95.8%, with specificity of 54.5%, 72.7% and 81.8%, with accuracy of 85.4%, 92.3% and 94.6%. Conclusion The sensitivity, specificity and accuracy of fine needle aspiration cytology combined thyroglobulin measurement in fine-needle aspiration biopsy were higher than that of fine needle aspiration cytology or thyroglobulin measurement in fine-needle aspiration biopsy alone, which can be used as a method of qualitative diagnosis during differentiated thyroid cancer postoperative follow-up. Key words: Thyroid neoplasms; Lymphatic metastasis; Biopsy, fine-needle; Thyroglobulin