Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning

The role of feedforward inhibition onto Purkinje cells during learning is still not well understood. Here, the authors report that selective genetic removal of GABAA receptor–mediated inhibition onto Purkinje cells modulates fine-scale patterns of Purkinje cell activity. These patterns may mediate the induction of downstream plasticity and, ultimately, the consolidation of cerebellar motor learning.