CDDO-Imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1

Xiaoli Meng,J. C. Waddington,Arun Tailor,Adam Lister,Jane Hamlett,Neil G. Berry,Kevin Park,Michael B. Sporn

CDDO-Imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1

2020

Xiaoli Meng
J. C. Waddington
Arun Tailor
Adam Lister
Jane Hamlett
Neil G. Berry
Kevin Park
Michael B. Sporn

Synthetic triterpenoids including CDDO, its methyl ester (CDDO-Me, bardoxolone methyl), and its imidazolide (CDDO-Im) enhance Nrf2-mediated antioxidant and anti-inflammatory activity in many diseas...

Keywords:

Chemistry
amino acid residue
Stereochemistry
KEAP1

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