Increased incidence of Anti - IgG of Coxsackievirus and Cytomegalovirus among diabetic children in Egypt.

Cytomegalovirus (CMV) and Coxsackievirus (CV) are included in the environmental factors potentially relevant to the pathogenesis of type 1 diabetes (T1D). Thus, this study aimed to detect the prevalence of both anti-IgG for each of CV and CMV in diabetic children with (EV + ) or without (EV - ) enteroviruses infection. The current study revealed that the T1D-EV + and T1D-EV - groups had marked elevations in hemoglobin A1c (HbA1c), C-reactive protein (CRP) and glutamic acid decarboxylase autoantibodies (GADA) as compared to non-diabetic control.  Moreover, anti-IgG for the CV and CMV groups were detected in three groups; diabetic infected (T1D-EV + ), diabetic non-infected (T1D-EV - ) and control group. Detection of anti-CV IgG achieved 22.7%, 6.7% and 64% in control, T1D-EV - and T1D-EV + , respectively. However, detection of anti-CMV IgG revealed 23.4%, 50% and 40% in control, T1D-EV - and T1D-EV + , respectively. In conclusion, the prevalence of the antibodies of CV-IgG and CMV-IgG in the sera of diabetic children more than that in healthy control children may give a role of these viruses in the etiology and progression of T1D.