Clinical Results: Myocardium

Because of the distribution of the CK isoenzymes in the organs, it was obvious that the hybrid form CK-MB capable of being quantified in the serum could present a sensitive marker for myocardial damage. The investigations conducted by Sjovall [743] contained early data regarding the occurrence of this isoenzyme in the serum of a patient after acute myocardial infarction. This observation was confirmed by van der Veen and Willebrands [826]. These authors found that this isoenzyme of CK moving between CK-MM and CK-BB in electrophoresis, was temporarily found in the serum of two patients with acute myocadial infarction. Identical results were obtained a short time later by Konttinen and Somer [399], who proved the existence of CK-MB isoenzyme in the serum of 19 out of 21 patients having acute myocardial infarction. Similar findings, confirming the value of the CK-MB isoenzyme in the diagnosis of myocardial infarction with the aid of electrophoretic and chromatographic separation methods, were reported in subsequent years by numerous groups[ 55, 182, 234, 263, 352, 400, 428, 430, 645, 646, 649, 664, 745, 829, 839, 886].