The first postoperative-stimulated serum thyroglobulin is a prognostic factor for thyroid microcarcinomas

Abstract Introduction Endogenous thyroid-stimulating hormone-stimulated thyroglobulin collected after total thyroidectomy is a useful predictor of better prognosis in patients with differentiated thyroid carcinomas in general, but studies with microcarcinomas are scarce. Objective To assess whether the first postoperative stimulated thyroglobulin measurement is a prognostic factor in patients with microcarcinoma. Methods The medical data of 150 differentiated thyroid carcinoma patients were studied retrospectively, and 54 (36%) cases with microcarcinoma were selected. The first postoperative stimulated thyroglobulin (1st stimulated thyroglobulin), measured after thyroidectomy, initial presentation data, and microcarcinomas treatment were assessed regarding outcome. Worse prognosis was defined as neoplasm persistence/recurrence. Results Persistence/recurrence occurred in 27.8% of the cases. These patients were identified according to the following parameters: receiving more than one 131 iodine dose (100% vs. 0%; p 131 iodine dose (232.14 ± 99.09 vs. 144 ± 33.61 mCi; p p p  = 0.019); and 1st stimulated thyroglobulin (19.01 ± 44.18 vs. 2.19 ± 2.54 ng/dL; p p  = 0.029] and follow-up time (odds ratio = 1.027; 95% confidence interval: 1.007–1.048; p  = 0.007) were independent predictors of risk of persistence/recurrence. The cutoff point of 1.6 ng/dL for the 1st stimulated thyroglobulin was significantly associated with disease persistence/recurrence [area under the curve = 0.713 ( p  = 0.019)]. Conclusion The first stimulated thyroglobulin predicted disease persistence/recurrence in patients with microcarcinoma.