Synthesis of Polycyclic Nitrogen Heterocycles via Cascade Pd-Catalyzed Alkene Carboamination/Diels-Alder Reactions

Cascade Pd-catalyzed alkene carboamination/Diels–Alder reactions between bromodienes and amines bearing two pendant alkenes are described. These transformations generate 4 bonds, 3 rings, and 3–5 stereocenters to afford polycyclic nitrogen heterocycles with high diastereoselectivity.