Luteal function in sheep with ovarian autotransplants given concurrent infusions of prolactin and prostaglandin F2α into the ovarian artery

Abstract Four experimental sheep with ovarian autotransplants were infused with prolactin (10 or 100 μg/h), into the ovarian artery, for 6 hours and then prolactin together with prostaglandin F 2α (PGF 2α ) (5 μg/h) for a further 6 hours. A control sheep received PGF 2α alone, for 6 hours on two separate occasions. Prolactin failed to overcome the luteolytic action of PGF 2α in 3 of the 4 experimental sheep.