Correlation of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with thrombolysis in myocardial infarction frame count in ST-segment elevation myocardial infarction

Background Impaired coronary artery reflow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated with post-intervention adverse effects. Thus finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, Platelet-to -Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) have been introduced. In the present study, we aimed to investigate correlation of PLR and NLR with Thrombolysis In Myocardial Infarction (TIMI) frame count. Materials and Methods A total of 215 consecutive patients with STEMI were recruited. Pre-intervention laboratory tests were performed. Moreover, PLR and NLR were calculated for each patient. Ultimately, TIMI frame count was assessed subsequent to primary PCI for each patient. Results We found that both PLR and NLR are correlated with TIMI frame count (R: 0.372, P value: <0.001 and R: 0.301, P value: <0.001, respectively). Furthermore, it was revealed that both PLR and NLR are positively correlated with corrected TIMI frame count (R: 0.388, P value: <0.001 and R: 0.290, P value: <0.001, respectively). Conclusions PLR and NLR are two easily calculated and efficient indexes for predicting the no-reflow phenomenon in patients with STEMI undergoing PPCI. Therefore, they might be employed in accurate risk stratification when a patient is a candidate for PPCI and in accurately referring patients who would benefit greatly from PPCI. This article is protected by copyright. All rights reserved.