Report of the Workshop on Controlled Release Dosage Forms: Issues and Controversies: Academy of Pharmaceutical Sciences American Society for Clinical Pharmacology 3 Therapeutics Drug Information Association and Food and Drug Administration

AbstractControlled release pharmaceutical dosage forms may offer one or several advantages over conventional dosage forms of the same drug, including reduced dosing frequency, decreased incidence and/or intensity of adverse effects, greater selectivity of pharmacologic activity and a more constant therapeutic effect. In other instances, controlled release products may have no significant advantages or they may actually be less effective and/or more hazardous than conventional dosage forms of the same drug. In some cases, controlled release products may be therapeutically advantageous primarily for certain subpopulations of patients.