Evaluation and Basic Study of Efficacy of AA-673 Nebulization Therapy for Perennial Allergic Rhinitis.

A single-blind study with envelopes of AA-673 for nebulization was conducted to assess its efficacy and to establish the proper dosage in the treatment of perennial allergic rhinitis. Some fun-damental conditions of nebulization were studied.1. AA-673 prevented histamine release from basophile in nasal fluid for 5 minutes, when 2.5 mg for 2 minutes was nebulized on in normal 7 volunteers.2. The clinical efficacy rate (good and excellent ratings combined) according to the doctors in charge was 33.3% for 0.85 mg vs. 71.4% for 2.5 mg.3. No side effects was found in treated patients.The above results suggest that AA-673 nebulization therapy is as effective as and sometimes more effective than, systemic therapy or nasal spray with AA-673.