Genetic variants in restless legs syndrome and Parkinson´s disease: the rare, the common and everything in between

Although genome-wide association studies (GWAS) have identified genetic risk factors involved in common, genetically complex diseases such as restless legs syndrome (RLS) or Parkinson`s disease (PD), much of the heritability remains to be explained. In this work, rare but also low-frequency and common variants were identified which contribute to the genetic architecture of both diseases and argue for the fact that, in line with the “common disease, rare variant” hypothesis, rare and low frequency variants next to common variants also contribute to the genetic framework of complex disorders.