Human mesangial cell-derived interleukin 8 and interleukin 6: modulation by an interleukin 1 receptor antagonist.

The position and properties of the mesangial cell confer a major role for these cells in the regulation of renal function (1,2). Mesangial cells reside in the intercapillary space of the glomerulus and are embedded in an extracellular matrix. The interstitial region is unique in that entry of substances from the capillary lumen to the intercapillary space occurs without crossing a capillary basement membrane, the area is therefore well suited for a sieving function.