Nanoparticles for the administration of DNA to a target organ.

Use of nanoparticles loaded with DNA for transfection of DNA into cells in vitro, wherein the cells are preferably eukaryotic cells, more preferably eucaryotic cells in culture and / or wherein the DNA is selected from the group consisting of plasmid DNAs and antisense oligonucleotides, preferably from the group consisting of plasmid DNAs comprising the information of tumor suppressor genes and antisense oligonucleotides against oncogenes, and / or wherein the DNA is transfected under the control of an inducible promoter, wherein the nanoparticles they prepared by polymerization from a monomer selected from alkylcyanoacrylates.