Экскреция высоколипофильного фенольного антиоксиданта у крыс

The process and pathways of excretion of high-lipophilicity (log P = 8.14) compound 4-methyl-2,6-diisobornylphenol (IBPH) from rat organism was investigated using HPLC by evaluating the renal excretion and elimination through the gastrointestinal tract (GIT) with feces and bile. IBPH was administrated orally in a single dose of 20 mg/kg with starch slime. Then, 81% of the administered amount was found in rat feces. The kinetics of drug excretion through the GIT revealed two phases of elimination: (1) rapid phase (within 24 h after IBPH administration), when 70% of the administered dose was excreted and (2) slow phase (within 24 – 96 h ) possibly related to elimination from depot tissues and organs. The IBPH concentration found in the bile is one order lower than that in the blood plasma, but the time of attaining the maximum concentration differs rather insignificantly. Despite high concentrations of IBPH in kidneys, the renal excretion pathway has appeared minor: the total amount of IBPH in urine for 4 days was only about 0.01% of the administered dose.