Titanium(IV) Chloride–Zinc

(TiCl4) [7550-45-0] Cl4Ti (MW 189.68) InChI = 1S/4ClH.Ti/h4*1H;/q;;;;+4/p-4 InChIKey = XJDNKRIXUMDJCW-UHFFFAOYSA-J (Zn) [7440-66-6] Zn (MW 65.39) InChI = 1S/Zn InChIKey = HCHKCACWOHOZIP-UHFFFAOYSA-N (combination of reagents which generates a divalent titanium chloride species: an oxophilic reducing agent used for carbonyl couplings1 and reduction of sulfoxides,2 etc.) Physical Data: see Titanium(IV) Chloride and Zinc. Solubility: TiCl4: sol aromatic hydrocarbons, ether, THF, dioxane, chlorohydrocarbons. Zinc: insol organic solvents. Form Supplied in: TiCl4: colorless liquid, or as a crystalline complex with THF; also supplied as solutions in toluene or dichloromethane. Zinc: metallic grey powder. Preparative Methods: zinc powder (3 equiv) is added slowly to a mixture of the reagent(s) and TiCl4 (1.5 equiv) in THF at −10 °C under argon. The mixture is then heated to the required temperature for an appropriate time. Handling, Storage, and Precautions: TiCl4 is corrosive and moisture sensitive. Zinc powder will react with water, liberating flammable gases and may spontaneously ignite in air. TiCl2 is moisture and oxygen-sensitive and all reagents and reaction mixtures should therefore be handled under a dry inert atmosphere. Solvents should be dried before use.