Tratamiento de la alopecia areata en placas con capsaicina en ungüento al 0.075

Introduction: Alopecia areata is considered a multifactorial disease, with genetic predisposition, wich pathogenically is a tissue specifi c, autoimmune disease that affects hair follicules in any body part, preferably in the scalp. Stress play a key role in the initiation and progression of AA wich has lead to investigation of pathways that link the nervus system and the immune system like the one that involves the neuropeptides substance P (SP), calcitonin-gene related peptide (CGRP), vasoactive intestinal (VIP) peptide as immunomodulators. In this base is postulated that topical capsaicin induce release of SP and after repeated application causes transient depletion of SP , leading to de growing of the hair follicle limiting the infl ammatory cascade. Methods: Randomized clinical, triple blind, placebo-controlled trial, effectiveness of capsaicin 0.075% in the treatment of alopecia areata. Results and discussion: These result are applicable to patients with diagnosis of AA SALT1 (with less than www.medigraphic.org.mx