Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses.
2013
Background
Corticotropin-releasing factor (CRF) plays an important role in affective states and disorders. CRF is not only a “stress hormone” but also a neuromodulator outside the hypothalamic-pituitary-adrenocortical (HPA) axis. The amygdala, a brain center for emotions, is a major site of extrahypothalamic expression of CRF and its G-protein-coupled receptors. Our previous studies showed that endogenous activation of CRF1 receptors in an arthritis pain model contributes to amygdala hyperactivity and pain-related behaviors. Here we examined the synaptic and behavioral effects of CRF in the amygdala of normal animals in the absence of tissue injury or disease.
Keywords:
- Amygdala
- Synapse
- Medicine
- Anesthesia
- Corticotropin-releasing hormone
- Neuroscience
- Pascal (unit)
- Corticotropin-releasing hormone receptor 1
- Neurotransmission
- Neurology
- Endocrinology
- Internal medicine
- Receptor
- Microdialysis
- Excitatory postsynaptic potential
- NMDA receptor
- Neural facilitation
- Central nucleus of the amygdala
- Postsynaptic potential
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
78
References
67
Citations
NaN
KQI