Tokolyse mit einem β-Mimetikum bei WPW-Syndrom

During a previous pregnancy supraventricular tachycardia complicated delivery in time in a woman with WPW-syndrome (Typ A) known since seven years. In the 34th week of the second pregnancy onset of preterm labor with a pelvic score of 7 and a tocolysis index of 5 was indication for tocolytic therapy. For protection against paroxysmal supraventricular tachycardia tocolysis with the semiselective beta 2-stimulating compound Fenoterol was started in combination with the beta 1-selective blocking compound Metoprolol. Tocolysis lasted 6 days without cardiac complications. Also during labor no tachycardia set on. The duration of tocolysis with Fenoterol/Metoprolol in this case was comparable with the duration of tocolysis reported for monotherapy with Fenoterol in similar obstetric states. In patients with WPW-syndrome the combination of a semiselective beta 2-simulating compound with a beta 1-blocking agent seems to offer a new possibility for tocolytic therapy.