A Phosphoinositide Code for Primary Cilia

How phosphoinositide metabolism is coupled to primary cilia physiology is poorly understood. Reporting recently in Developmental Cell , Chavez et al. (2015) and Garcia-Gonzalo et al. (2015) show that INPP5E-mediated phosphoinositide metabolism, which creates a specific phosphoinositide distribution, ensures proper protein trafficking and Hh signaling in primary cilia.