Resposta imune humoral de cães domésticos que receberam dose única de vacina antivírus da raiva

The National Programme for Rabies Prevention aims to maintain immunogenic protective levels in vaccinated animals, with titers of neutralizing antibodies (VNA) ≥ 0.5 IU / mL. The aim of this study was to evaluate, according to age, race, and the period of vaccination and blood collection, the immune response in dogs that received a single dose of rabies vaccine virus in cell culture. In this study 432 samples received at the Pasteur Institute of Sao Paulo in the triennium 2009-2011 were analyzed. Data were analyzed and the evaluation of the VNA to rabies virus was performed by rapid fluorescent inhibition test foci (RFFIT). Of the total samples analyzed, 21.76% did not have protective titers. Among these, 67.02% samples were considered puppies and when the interval between the date of vaccine administration and blood collection, 60.63% samples did not reach the titration in the first six months. It was concluded from this study sample the need for a second dose of vaccine in puppies, as they are more susceptible to infection by rabies virus, which would increase the possibility of a rapid and durable response.