Hypertension and Thrombosis, Genetic Determinants of Cardiovascular Disease

Applying our growing understanding of genes that promote hypertension in humans should lead to more accurate diagnoses and more effective treatment. Furthermore in some cases it can already help us prevent avoidable early deaths. This discussion covers several dominant endocrine syndromes causing severe hypertension and preventable early deaths. We also discuss a very common genetic variant at the angiotensinogen locus that seems to be a gene for “salt sensitive hypertension.”