Определение концентрации бортезомиба в плазме крови с помощью разработанной методики LC/MS

The concentration of bortezomib in patients with multiple myeloma by method of liquid chromatography with mass spectrometric detection after a single i/o bolus injection at a dose of 3,5 mg via peripheral or central venous catheter venous drug Velcade ("Janssen-Cilag International NV" Belgium) was measured. It is shown that the maximum concentration of bortezomib after a single i/о administration is achieved almost immediately and becomes equal to 93,5±54,7. After that the concentration of bortezomib in plasma decreases sharply, moving to longer distribution phases and the terminal phase. In this process a pronounced individual variation of values (33 to 62%) is registered. Average values of bortezomib concentration for each moments of time did not differ statistically significantly.