Report of a patient with typical progeria, including data from urinary hormone studies.

THE syndrome of true progeria, first described by Hutchinson (1) in 1886 and further classified by Gilford (2) in 1904, has been reported since that time only on rare occasions. A recent review of the world literature by Thomson and Forfar(3) lists only 19 reports of typical progeria, including their own patient. Wilkins (4) has recently described another patient. The diagnosis is based on the bizarre appearance of the patient and thus far no definitive biochemical laboratory findings have been established. The description of our patient, W. R., and his photographs are typical of classic progeria. The long period of his followup and the data of his urinary hormone excretion appeared to warrant this report. The necropsy findings reported by Gilford (2), Orrico and Strada (5) and Talbot et al. (6) give supportive evidence to the clinical impression of premature aging. These findings include advanced arteriosclerotic changes, atherosclerosis of the aorta, narrowing of the coronary arteries and calcareous dep...