Mechanism and rule of nitric oxide release from cerebral microvessel in gerbils with cerebral ischemia

Objective To investigate the changes of NO as well as the effect of blocked choline receptor in pia mater microarteries in gerbils with cerebral ischemia. Methods A total of 16 gerbils were inflicted with bilateral common carotid arteries and divided into ischemic group and ischemia+atropine, the other 8 animals served as control. The changes of NO were measured with electrical chemistry. Results During cerebral ischemia, the NO was increased in pia mater microartery and released periodically for 3～5 min in an interval of 5～8 min and continued. When atropine (0.1mmol/L) was dropped onto the surface of gerbil's brain, the periodical release of NO disappeared, but the NO was still higher in pia mater microarteries than basic content. Conclusion The NO release from cerebral microvessel may be partly regulated by acetycholine during cerebral ischemia.