Self-projection and the default network in frontotemporal dementia

Self-projection allows an individual to remember the past, simulate the future and imagine the viewpoints of others, and seems to be mediated by key frontal and temporal lobe regions of the so-called default network of the brain. Irish and colleagues discuss pathological changes to the default network and self-projective functions in patients with frontotemporal dementia (FTD), focusing on behavioral variant FTD and semantic dementia.