Abstract 14944: Improved Assessment of Coronary Artery Stenosis Severity Using Combined Anatomical and Functional Endpoints: A Clinical Study

Introduction: During cardiac catheterization, functional severity of blockages is assessed using diagnostic parameters, like Fractional Flow Reserve (FFR, pressure based) and Coronary Flow Reserve (CFR, flow based). However, the complex hemodynamics of stenosis might not be sufficiently explained by either pressure or flow alone, particularly in the case of intermediate stenosis. Therefore, based on fluid dynamic principles, we have defined two parameters, Pressure Drop Coefficient (CDP, functional endpoint), based on both pressure and flow, and Lesion Flow Coefficient (LFC), that combines anatomical (area stenosis, %AS) and functional endpoints (Table 1). Hypothesis: We hypothesize that the CDP will correlate better when FFR and CFR are combined and the LFC will correlate when FFR, CFR and %AS are combined. Methods: The protocol for this clinical study was approved by the IRB at the University of Cincinnati and Veteran Affairs Medical Center. Patients with reversible perfusion defects as per SPECT scan w...