Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)

Koen P. Rovers,Checca Bakkers,Geert A. A. M. Simkens,Jacobus W. A. Burger,Simon W. Nienhuijs,Geert-Jan Creemers,Anna M. J. Thijs,Alexandra R.M. Brandt-Kerkhof,E. Madsen,Ninos Ayez,Nadine L. de Boer,Esther van Meerten,Jurriaan B. Tuynman,M. Kusters,Nina R. Sluiter,Henk M.W. Verheul,Hans J. van der Vliet,Marinus J. Wiezer,Djamila Boerma,Emma C E Wassenaar,Maartje Los,Cornelis B. Hunting,Arend G. J. Aalbers,N. Kok,Koert Kuhlmann,Henk Boot,Myriam Chalabi,Schelto Kruijff,Lukas B. Been,Robert J. van Ginkel,Derk Jan A. de Groot,Rudolf S. N. Fehrmann,Johannes H. W. de Wilt,A.J.A. Bremers,Philip R. de Reuver,Sandra A. Radema,Karin H. Herbschleb,Wilhelmina M. U. van Grevenstein,Arjen J. Witkamp,Miriam Koopman,Nadia Haj Mohammad,Eino B. van Duyn,Walter J.B. Mastboom,Leonie J. M. Mekenkamp,Joost Nederend,Max J. Lahaye,Petur Snaebjornsson,Cornelis Verhoef,Hanneke W. M. van Laarhoven,Aeilko H. Zwinderman,Jeanette M. Bouma,Onno Kranenburg,Iris van ‘t Erve,Remond J.A. Fijneman,Marcel G. W. Dijkgraaf,Patrick H. J. Hemmer,Cornelis J. A. Punt,P. J. Tanis,Ignace H. de Hingh

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)

2019

Koen P. Rovers
Checca Bakkers
Geert A. A. M. Simkens
Jacobus W. A. Burger
Simon W. Nienhuijs
Geert-Jan Creemers
Anna M. J. Thijs
Alexandra R.M. Brandt-Kerkhof
E. Madsen
Ninos Ayez
Nadine L. de Boer
Esther van Meerten
Jurriaan B. Tuynman
M. Kusters
Nina R. Sluiter
Henk M.W. Verheul
Hans J. van der Vliet
Marinus J. Wiezer
Djamila Boerma
Emma C E Wassenaar
Maartje Los
Cornelis B. Hunting
Arend G. J. Aalbers
N. Kok
Koert Kuhlmann
Henk Boot
Myriam Chalabi
Schelto Kruijff
Lukas B. Been
Robert J. van Ginkel
Derk Jan A. de Groot
Rudolf S. N. Fehrmann
Johannes H. W. de Wilt
A.J.A. Bremers
Philip R. de Reuver
Sandra A. Radema
Karin H. Herbschleb
Wilhelmina M. U. van Grevenstein
Arjen J. Witkamp
Miriam Koopman
Nadia Haj Mohammad
Eino B. van Duyn
Walter J.B. Mastboom
Leonie J. M. Mekenkamp
Joost Nederend
Max J. Lahaye
Petur Snaebjornsson
Cornelis Verhoef
Hanneke W. M. van Laarhoven
Aeilko H. Zwinderman
Jeanette M. Bouma
Onno Kranenburg
Iris van ‘t Erve
Remond J.A. Fijneman
Marcel G. W. Dijkgraaf
Patrick H. J. Hemmer
Cornelis J. A. Punt
P. J. Tanis
Ignace H. de Hingh

Background Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands. This study investigates whether addition of perioperative systemic therapy to CRS-HIPEC improves oncological outcomes.

Keywords:

Medicine
Standard treatment
Systemic therapy
Perioperative
Surgery
Bevacizumab
Irinotecan
Oxaliplatin
Hyperthermic intraperitoneal chemotherapy
FOLFIRI
Cancer research
Neoadjuvant therapy
FOLFOX

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