Early declines in physical function among aging adults with type 2 diabetes

Abstract Aims Type 2 diabetes (T2DM) is associated with reduced physical function and early disability. We hypothesized that changes in physical function occur early and differ by age. Our aims were to determine and compare differences in and predictors of physical function in older and younger adults with T2DM. Methods Eighty adults completed six-minute walk distance (6MWD) tests, wore wrist actigraphy for 5 days and completed diabetes health and symptom surveys. Comparative and bivariate analyses were completed to assess differences between age groups determined by serial Box's M-plot analyses. Results 6MWD was low (476.9 ± 106.2 m), and negatively associated with female gender, age, neuropathic pain, diabetes duration, BMI, poor sleep quality, and fatigue and positively with habitual activity and education ( p R 2  = 0.593, p R 2  = 0.554, p Conclusions T2DM is associated with early declines in physical function; the predictors of which change in midlife. Therapies to maintain or improve physical function should be tailored by age, pain symptoms, and habitual activity levels.