ANTIFUNGAL ACTIVITY AND SYNERGY STUDIES OF POLYSUBSTITUTED ALICYCLIC ANALOGUES

Opportunistic mycosis is mainly caused by Candida and Aspergillus species. There have been several recent case reports of pulmonary aspergillosis caused by Aspergillus niger. In our research on anti-infective agents, a series of polysubstituted cyclohexanone derivatives were synthesized and showed good in-vitro growth inhibitory activity against Aspergillus niger and the CC50 values indicate that the compounds are relatively less toxic. The most active compound showed synergy with Clotrimazole and exhibited thirty-three fold improvements in activity. Fractional inhibitory concentration index (FICI) was found to be 0.33. Thus, the newly synthesized polysubstituted alicyclic compounds are good hits and the most active derivative could serve as a potential lead.