Den "Zucker" zügeln Zusammenhänge zwischen Ballaststoffzufuhr und Diabetesrisiko Reining Back Diabetes Associations Between Intake of Dietary Fibre and Risk of Diabetes

In epidemiological studies, cereal fibres were found to reduce the incidence of cardiovascular diseases and type 2 diabetes. The beneficial ef- fects have been proved primarily for insoluble fi- bres. In human studies, administration of insolu- ble, non-fermentable oat fibres has shown a clear improvement in insulin sensitivity. This result was observed in young, slim subjects as well as in older, overweight ones. The datawere confirm- ed in the ProFiMet study. In this study, insoluble oat fibres were given as a supplement over 18 weeks and were compared with placebo, pro- tein-rich nutrition, and a combined protein-fibre supplement. A higher protein intake adversely af- fected insulin sensitivity, whereas the measure- ments improved under the influence of the oat fi- bre and the combination of oat fibre and protein. High-protein nutrition obviously induces insulin resistance by activating S6 kinase. Insoluble fibres prevent this, presumably owing to a modification of the fermentation processes in the large intes- tine. They prevent protein absorption through the bowel and block the activation of S6 kinase. In a current study, 200 subjects with prediabetes are receiving cereal fibres and are observed over two years in a placebo-controlled setting. It is ho- ped that the results will show that the insoluble fibres can lower the risk for a manifestation of diabetes. A notable increase in the daily intake of insoluble dietary fibres in the context of nutrition is desirable, but not practical. An alternative solu- tion is the fortification of diverse foodstuffs with fibres, ranging from bread to sausages and meats. Dieses Dokument wurde zum personlichen Gebrauch heruntergeladen. Vervielfaltigung nur mit Zustimmung des Verlages.