Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing
2003
Fission yeast does not form synaptonemal complexes in meiotic prophase.
Instead, linear elements appear that resemble the axial cores of other
eukaryotes. They have been proposed to be minimal structures necessary for
proper meiotic chromosome functions. We examined linear element formation in
meiotic recombination deficient mutants. The rec12, rec14 and
meu13 mutants showed altered linear element formation. Examination of
rec12 and other mutants deficient in the initiation of meiotic
recombination revealed that occurrence of meiosis-specific DNA breaks is not a
precondition for the formation of linear elements. The rec11 and
rec8 mutants exhibited strongly impaired linear elements with
morphologies specific for these meiotic cohesin mutants. The rec10
and rec16/rep1 mutants lack linear elements completely. The region
specificity of loss of recombination in the rec8, rec10 and
rec11 mutants can be explained by their defects in linear element
formation. Investigation of the rec10 mutant showed that linear
elements are basically dispensable for sister chromatid cohesion, but
contribute to full level pairing of homologous chromosomes.
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