Population pharmacokinetics of rectal theophylline in neonates

Summary:The population pharmacokinetics of theophylline were studied in 35 neonates receiving aminophylline suppositories for the treatment of apnoea of prematurity. Routinely measured theophylline serum concentrations (n = 138, range 3–20 mg/L) were modelled in NONMEM according to a one-compartment