Disposition and metabolism of [14C]sparfloxacin in the rat.
1991
Disposition and metabolism of [carbonyl- 14 C]sparfloxacin SPFX, 5-amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-pi-perazinyl/-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, AT-4140; CAS 1108 71-86-8/, a novel antimicrobial quinolone, were studied in rats mainly after oral administration at 10 mg/kg. SPFX was absorbed from the whole area of small intestine as shown by the loop method
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