FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF SERTACONAZOLE NITRAT E

The present work was designed to develop suitable transderma l matrix patch of sertaconazole nitrate, which is of the imidazole class used for antifungal medication, using Ethyl cellulose (EC), Polyvinyl pyrrolidone (PVPK - 30) and Dibutyl phthalate. The aqueous insolubility of the drug ins pires for the formulation of controlled release transdermal patches. Different batches developed using Ethyl cel lulose and Polyvinyl pyrrolidone in different ratios by solvent evaporation technique. Drug excipient interaction study was further carried out using Fourier Transform Infrared (FTIR) spec troscopic technique. Physical evaluation performed such as moisture content, moisture uptake, thickness and folding endurance. In vitro diffusion studies were performed using cellulose nitrate membrane (pore size 0.45μ) in modified Franz’s diffusion cells in buffer of pH 7.4. Permeation stud ies illustrated that the ratio of polyvinyl pyrrolidone and ethyl cellu lose 1:5 shows good controlled release. Higuchi and Korsmeyer - Pepp as models were used for optimizing the formulation .