Research on the Preventive and Therapeutic Effects of Kadsura coccinea on Experimental Hepatic Fibrosis in Rat and the Related Mechanism

Objective:To discuss the preventive and therapeutic effects of Kadsura coccinea on experimental hepatic fibrosis in rat and to explore its mechanism.Method:The rat model of hepatic fibrosis was induced by giving CCl4,rich fat and poor protein.Having a controlled trial with colchicines,Kadsura coccinea’s effects on alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(Alb),hyaluronate acid(HA),laminin(LN),type Ⅲ procollagen(PC Ⅲ) in serum and malondialdehyde(MDA),dismutase(SOD),hydroxyproline(Hyp) in liver tissue were determined.The pathological section of the rat’s liver was examined under an optical microscope.Result:Kadsura coccinea significantly decreased the activity of ALT,AST and the level of HA,LN,PCⅢ in rat serum,and the level of Hyp,MDA in liver tissue.It also increased the level of Alb in serum and the activity of SOD in liver tissue.The degree of necrosis of liver cells,liver fat’s degeneration and collagen fiber hyperplasia were alleviated significantly.Conclusion:Kadsura coccinea shows significant preventive and therapeutic effects on experimental hepatic fibrosis.The possible mechanism of its preventive and therapeutic effects may be related to its anti-lipid peroxidation.