RANTES-403G/A、MCP-1-2518A/G基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性

Objective: To explore the correlation of regulated on activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) gene polymorphisms with the susceptibility of respiratory syncytial virus (RSV) bronchiolitis. Methods: RANTES403G/A and MCP-1-2518A/G were genotyped with polymerase chain reaction-restriction fragment length polymorphism in 150 children with RSV bronchiolitis and 120 healthy subjects. Results: The frequency of each genotype for RANTES-403G/A was 20.7% (GG), 63.3% (GA), 16.0% (AA) in case group and 37.5% (GG), 46.7% (GA), 15.8% (AA) in control one, respectively. There was significant difference between two groups (P＜0.05). The frequency of each allele was 52.3% (G), 47.7% (A) in case group, and 60.8% (G), 39.2% (A) in control group. The frequency of A allele was significantly increased in case group (P＜0.05); Children carrying with A allele increased risk for RSV bronchiolitis compared with those with G allele (OR=1.415, P＜0.05). There were no significant differences for genotype and allele frequency of MCP-1-2518A/G between two groups (P＞0.05). Conclusion: RANTES-403A allele is associated with the susceptibility and may be one of candidate genes for RSV bronchiolitis. No correlation is found between MCP1-2518A/G gene polymorphisms and the susceptibility of RSV bronchiolitis.