A New Series of Antifungal Compounds

Compounds of the type ArCH(OR)CBr-(NO2)R′ have been found to possess strong antifungal activity. The preparation, properties, and antifungal activities of a number of compounds of this formula are described. 2-Bromo-1-methoxy-2-nitro-1-phenylpropane has been further tested and ointments containing it have been prepared and submitted for clinical trial. Results from one of these trials have been published.