The association between genetic polymorphisms of IL-6 and the susceptibility of chronic rhinosinusitis

Objective:To investigate the relationship between the promoter polymorphism of IL6(-174GC,-572GC and-597GA) and chronic rhinosinusitis(CRS).Method:The case-control study consisted of 123 patients with CRS and 239 controls from a Chinese Han population from Shanghai.The genotypes of the subjects were determined by polymerase chain reaction-restriction fragment length polymorphism and gene sequencing.Besides,the concentrations of the totle immunoglobulin E(TIgE) and eosinophilic cationic protein(ECP) in the blood were also determined.Result:The-174GC and-597GA polymorphisms were not detected in this study population.Significant differences in genotype and allele frequencies of-572C/G were observed between CRS patients and control groups.In CRS pations,the CC,CG,GG genotype frequencies were 69.1%,29.3%,1.6%,C,G allele frequencies were 83.7%,16.3%.In control group,the genotype frequencies were 55.2%,42.3%,2.5%,the allele frequencies were 76.4%,23.6%,respectively.The-572CC genotype was associated with an increased risk of developing CRS(P0.05,OR=1.932,95%CI,1.205-3.097).There was no significant differences in the concentrations of the TIgE and ECP among each genotype.Conclusion:IL-6 gene-572GC polymorphism is associated with the susceptibility to CRS.CC genotype could be an independent risk factor.