Hybrid wireframe DNA nanostructures with scaffolded and scaffold‐free modules

Scaffolded DNA origami approach and scaffold-free LEGO approach both demonstrate extraordinary self-assembly capability for the construction of all kinds of complex DNA nanostructures. Combining the construction elements of the two approaches, we introduce a hybrid framework to build wireframe structures in this study. A collection of two-dimensional (2D) and three-dimensional (3D) wireframe structures are presented to showcase the simple and versatile design scheme. Our development reveals more of the ever-expanding design space of structural DNA nanotechnology.