Effect of Jiawei Xiaoyaosan on monoamine neurotransmitter in patients with psychological stress insomnia

Objective:To investigate effect of Jiawei Xiaoyao San on monoamine neurotransmitter in patients with psychological stress insomnia.Methods:A randomized controlled study was conducted in 33 cases with psychological stress insomnia.They were assigned to the TCM group(treated with Jiawei Xiaoyao San),the western medicine group(treated with Estazolam),the integrated medicine group(treated with Jiawei Xiaoyao San and Estazolam)and the control group(treated with placebo of Jiawei Xiaoyao San and Estazolam).Serum levels of monoamine neurotransmitter and their metabolites(NE,DA,5-HT, 5-HIAA,5-HIAA/5-HT)were detected before and at the 6th week of the treatment.Results:NE:After 6 weeks of treatment, serum levels of NE has no significant difference in 3 groups(P0.05),but the serum NE level was decreased obviously in control group(P0.05).DA:After 6 weeks of treatment,the serum DA level was increased in TCM group(P0.05),serum levels of DA has no significant difference in arther 3 groups(P0.05).5-HIAA and 5-HIAA/5-HT:After 6 weeks of treatment,the serum 5-HT level and ratio of 5-HIAA/5-HT decreased in the integrated medicine group(P0.05),the serum 5-HT level and ratio of 5-HIAA/5-HT have no significant difference in TCM,western medicine and control group(P0.05).Conclusions:The integrated medicine can regulate monoamine neurotransmitter to some extent.