Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits

Jason C. You,Kavitha Muralidharan,Jin W Park,Iraklis Petrof,Mark S. Pyfer,Brian F. Corbett,John LaFrancois,Yi Zheng,Xiaohong Zhang,Carrie A. Mohila,Daniel Yoshor,Robert A. Rissman,Eric J. Nestler,Helen E. Scharfman,Jeannie Chin

Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits

2017

Jason C. You
Kavitha Muralidharan
Jin W Park
Iraklis Petrof
Mark S. Pyfer
Brian F. Corbett
John LaFrancois
Yi Zheng
Xiaohong Zhang
Carrie A. Mohila
Daniel Yoshor
Robert A. Rissman
Eric J. Nestler
Helen E. Scharfman
Jeannie Chin

In rodent models of Alzheimer's disease (AD) and epilepsy, seizure-dependent induction of ΔFosB results in epigenetic silencing of calbindin. Hippocampal inhibition of ΔFosB or elevation of calbindin rescues spatial memory deficits in mouse models of AD.

Keywords:

Epilepsy
Hippocampal formation
Epigenesis
Gene silencing
Endocrinology
Transgene
Epigenetics
Hippocampus
Calbindin
Internal medicine
Biology
Temporal lobe
Dentate gyrus
Transcription factor

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations