Thiophilic conjugate between an oligonucleotide comprising a solid phase and thiooxothiazolidinyl nucleotides

The present invention is an oligonucleotide - relates solid conjugate, wherein the solid phase is a thiophilic, wherein the oligonucleotide comprises a thioxo nucleobases according to at least one of formula I: Wherein, X is CH or N, wherein R1 is H or NH2, wherein --- represents a covalent bond, wherein said thioxo the oligonucleotide to the solid phase of the which is attached via a sulfur atom of the nucleotide. It also discloses a variety of uses for the method and such oligonucleotides metal conjugates for producing such conjugates. .FIELD 1