Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as inhibitor of aldose reductase 2

Design and synthesis of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC 50 = 21.7 ∼ 45.3 μM) for the aldose reductase 2 (ALR2).