Primary Follicular Lymphoma of the Testis in Children and Adolescents

This study reports six cases of primary follicular lymphoma of the testis (PFLT) in children and adolescents correlated with clinical presentation, pathologic features, treatment and outcome. All six patients (ages 3 to 16 years, median 4 years) had PFLT grade 3 with disease limited to the testis, completely resected and treated with two courses of chemotherapy (cyclophosphamide, vincristine, prednisone, doxorubicin) (COPAD). Event-free survival was 100% (follow-up: median 73 months, mean 53 months, range 6 to 96 months). In conclusion, clinical outcome in children and adolescents with PFLT is excellent with treatment including complete surgical resection and two courses of COPAD.