29 DOES INDOMETHACIN (I) INCREASE THE RISK OF GENTAMICIN (G) TOXIITY IN VERY LOW BIRTH-WEIGHT INFANTS?

To confirm the hypothesis that I modifies G pharmacokinetic with high risk of toxicity, we studied 48 neonates (mean gestational age (GA) 28.3 w., birth-weight 1125 g, postnatal age 4.5 d.) affected by respiratory problems and treated with following schedule ol G administration: 2.5 mg(Kg/dose every 24 h for GA <32 w. and every 18 h for GA 32-34 w. Twenty-eight neonates were treated only with G (group 1) and twenty were also treated with I (group 2). The serum G concentrations (immunofluorescence assay) were (mcg/ml):