Pharmaceutical compositions with antimicrobial agents phosphonium

An ophthalmic pharmaceutical composition comprising: an antimicrobial agent phosphonium hexafluorophosphate according to the following formula: wherein: R1, R2, R3 and R4 are selected, independently, from the group consisting of H, alkyl, aryl, alkoxy, hydroxyl, hydroxyalkyl or alcohol; and X- is a counterion, and water; wherein the antimicrobial agent is at least phosphonium 0.0001% w / w of the composition and not more than 0.5% w / w; and wherein the composition is suitable for parenteral, oral or topical administration to a human; and wherein: i. at least two of R1, R2, R3 and R4 are selected from one or more hydroxy groups; or ii. at least one of R1, R2, R3 and R4 is a long chain alkyl of at least 8 carbon atoms; or iii. both of them