Porcine mesothelium matrix as a biomaterial for wound healing applications

Abstract The increasing economic burden of wound healing in healthcare systems requires the development of functional therapies. Xenografts with preserved extracellular matrix structure and biofunctional components overcome major limitations of autografts and allografts (e.g. availability) and artificial biomaterials (e.g. foreign body response). Although porcine mesothelium is extensively used in clinical practice, it is under-investigated for wound healing applications. Herein, we compared the biochemical and biological properties of the only two commercially available porcine mesothelium grafts (Meso Biomatrix® and Puracol® Ultra ECM) to traditionally used wound healing grafts (Endoform™, ovine forestomach and MatriStem®, porcine urinary bladder) and biomaterials (Promogran™, collagen/oxidised regenerated cellulose). The Endoform™ and the Puracol® Ultra ECM showed the highest (p 0.05) response to enzymatic degradation, whereas the Promogran™ was not completely degraded by MMP-8 and was completely degraded by elastase. The Promogran™ showed the highest (p